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Maxitrol (Neomycin, Polymyxin B and Dexamethasone)

Maxitrol (Neomycin, Polymyxin B and Dexamethasone)

Description

Generic Name: neomycin sulfate, polymyxin B sulfate and dexamethasone
Dosage Form: Ophthalmic Ointment

Maxitrol (neomycin and polymyxin B sulfates and dexamethasone ophthalmic ointment) is a multiple dose anti-infective steroid combination in sterile ointment form for topical application.
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Maxitrol eye drops (5 ml)
Manufacturer: Alcon-Couvreur N.V.
Brand name: Maxitrol
Generic name: Neomycin, Polymyxin B and Dexamethasone
Delivery time: Approx. 14-21 days
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1 bottle(s) $12.50 $12.50 $11.25  
5 bottle(s) $12.50 $62.50 $56.25  
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Established Name: Dexamethasone
Chemical Name: Pregna-1, 4-diene-3, 20-dione, 9-fluoro-11, 17, 21-trihydroxy-16-methyl-, (11², 16±)-.

Each gram contains: Active: neomycin sulfate equivalent to neomycin 3.5 mg, polymyxin B sulfate 10,000 units, dexamethasone 0.1 %.

Preservatives: methylparaben 0.05%, propylparaben 0.01%. Inactives: white petrolatum, anhydrous liquid lanolin.

Indications and Usage for Maxitrol

For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists.

Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns; or penetration of foreign bodies.

The use of a combination drug with an anti-infective component is indicated where the risk of infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye.

The particular anti-infective drug in this product is active against the following common bacterial eye pathogens:

Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa.

Maxitrol does not provide adequate coverage against: Serratia marcescens and Streptococci, including Streptococcus pneumoniae.

Contraindications for use Maxitrol

Epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva. Mycobacterial infection of the eye. Fungal diseases of ocular structures. Hypersensitivity to a component of the medication. (Hypersensitivity to the antibiotic component occurs at a higher rate than for other components.)

Precautions


The initial prescription and renewal of the medication order beyond 8 g should be made by a physician only after examination of the patient with the aid of magnification, such as a slit lamp biomicroscopy and, where appropriate, fluorescein staining.

The possibility of persistent fungal infections of the cornea should be considered after prolonged steroid dosing. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial ocular infection.

Do not use the product if the imprinted carton seals have been damaged, or removed.

Maxitrol Dosage and Administration

Apply a small amount into the conjunctival sac(s) up to three or four times daily.

How to Apply Maxitrol (neomycin and polymyxin B sulfates and dexamethasone ophthalmic ointment):

   1. Tilt your head back.
   2. Place a finger on your cheek just under your eye and gently pull down until a "V" pocket is formed between your eyeball and your lower lid.
   3. Place a small amount (about 1/2 inch) of Maxitrol (neomycin and polymyxin B sulfates and dexamethasone ophthalmic ointment) in the "V" pocket. Do not let the tip of the tube touch your eye.
   4. Look downward before closing your eye.

Not more than 8 g should be prescribed initially and the prescription should not be refilled without further evaluation as outlined in PRECAUTIONS above.