ACTIVITY:
Piracetam (Nootropil) acts on the central nervous system by means of different mechanisms.  It modulates cerebral neurotransmission, is a neuronal protector improving metabolic conditions at the cell level and, although not a vasodilator, improves microcirculation on account of its haemorrheological properties.

INDICATIONS:
Attention and memory disorders, problems affecting day-to-day activity and adaptation to the environment accompanying states of mental deterioration owing to:

• Degenerative vascular cerebral pathology related to age.
• Ischemic cerebrovascular pathology.
• Cortical myoclonias.

CONTRAINDICATIONS:
Piracetam (Nootropil) should not be taken by patients with serious renal insufficiency (creatinine clearance lower than 20 ml/min).

PRECAUTIONS:
Since Piracetam (Nootropil) is eliminated in urine, patients with renal insufficiency should take this drug with caution.

Abrupt suspension of treatment should be avoided, since this can cause a myoclonic or general crisis in certain myoclonic patients.

INTERACTIONS:
A single case has been reported in which the concomitant use of Piracetam (Nootropil) and thyroid hormone extracts (T3 + T4) has produced confusion, irritability and sleeping disorders. Its interaction with other drugs has not been described.