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Common name
Warfarin
Description
Active Ingredients:
Warfarin
Therapeutic actions:
Warfarin and other coumarin anticoagulants act by inhibiting the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. Half-lives of these clotting factors are as follows: Factor II - 60 hours, VII - 4-6 hours, IX - 24 hours, and X - 48-72 hours. The half-lives of proteins C and S are approximately 8 hours and 30 hours, respectively. The resultant in vivo effect is a sequential depression of Factor VII, Protein C, Factor IX, Protein S, and Factor X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of γ-carboxyglutamic acid residues in the proteins which are essential for biological activity. Warfarin is thought to interfere with clotting factor synthesis by inhibition of the regeneration of vitamin K1 epoxide. The degree of depression is dependent upon the dosage administered. Therapeutic doses of warfarin decrease the total amount of the active form of each vitamin K dependent clotting factor made by the liver by approximately 30% to 50%.
What is it used for?:
Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, and pulmonary embolism, for the prophylaxis and/or treatment of the thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement, to reduce the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction.
Contraindications and cautions:
• allergy to any ingredient in Warfarin
• bleeding tendencies, bleeding problems (eg, hemophilia), severe or uncontrolled high blood pressure, certain blood problems (eg, low white blood cell or platelet levels), or leukemia
• active serious bleeding, bleeding in the brain, certain blood vessel problems (eg, aneurysm, dissecting aorta), or inflammation or infection of the heart
• active ulcer or bleeding of the stomach or bowel, urinary tract, genitals, or respiratory tract
• recent or future eye, brain, or spinal cord surgery; spinal puncture; spinal anesthesia; or any type of major surgery
• pregnancy or possibility to become pregnant
Side effects:
Inform your doctor if you have these serious side effects:
Severe allergic reactions (itching; rash; hives; tightness in the chest; difficulty breathing; swelling of the mouth, face, lips, or tongue); back, side, muscle, joint, or stomach pain; black, tarry, or bloody stools; blood in the urine (pink or brown urine); chest pain; dizziness; unexplained swelling; fainting; numbness or tingling; pain, unusual color, or temperature change in any area of the body; pale skin; purple, dark, or painful toes; shortness of breath; wounds or sores that do not heal properly; skin sores or ulcers; stroke symptoms (eg, confusion, slurred speech, vision problems, one-sided weakness); sudden severe pain in your legs, feet, or toes; trouble swallowing; bloody or coffee ground-like vomit; unusual bruising or bleeding (eg, nosebleed, unusual bleeding from gums, increased bleeding from cuts, increased menstrual or vaginal bleeding, coughing up blood); unusual headache or weakness; fever; decreased urination; unusual pain, swelling, or discomfort; yellowing of the skin or eyes.
Interactions:
• Heparin or other anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), salicylates (eg, aspirin), streptokinase, or urokinase because the risk of bleeding may be increased
• Mifepristone because excessive bleeding may occur
• Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, high blood pressure, high cholesterol, seizures, mental or mood problems, diabetes, stomach or bowel problems, irregular heartbeat, birth control, hormone replacement, cancer, and others), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. Johnis wort) may interact with Warfarin, increasing the risk of serious side effects such as bleeding or blood clots
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Warfarin brands
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Product |
Manufacturer |
Price |
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Warfarex
30 tablets (3 mg/tablet)
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Grindex, Latvia |
$6.00 |
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Warfarex
30 tablets (5 mg/tablet)
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Grindex, Latvia |
$9.00 |
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Warfarin
30 tablets (3 mg/tablet)
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Orion Corporation, Finland |
$12.00 |
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Warfarin
100 tablets (5 mg/tablet)
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Orion Corporation, Finland |
$22.00 |
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