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Common name
Suprastin (Chloropyramin)
Description
Suprastin is an antihistamine used to treat the symptoms for the treatment of allergic conjuctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions.
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Active Ingredients:
Chloropyramin
Therapeutic actions:
Chloropyramine is known as a competitive reversible H1-receptor antagonist (also known as an H1 inverse agonist), meaning that it exerts its pharmacological action by competing with histamine for the H1 subtype histamine receptor. By blocking the effects of histamine, the drug inhibits the vasodilatation, increased vascular permeability, and tissue edema associated with histamine release in the tissue. The H1-antagonistic properties of chloropyramine can be used by researchers for the purposes of blocking the effects of histamine on cells and tissues. In addition, chloropyramine has some anticholinergic properties.
Indications:
Chloropyramine is a classical ("old" or first generation) antihistamine drug approved in Eastern European countries for the treatment of allergic conjuctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Related indications for clinical use include Quinckeis edema, allergic reactions to insect bites, food and drug allergies, and anaphylactic shock.
Contraindications and cautions:
Hypersensitivity, pregnancy, lactation period, narrow-angle glaucoma, hyperplasia of prostate gland, respiratory insufficiency, early breast age (to 1 mo.)use with caution. Peptic ulcer of GIT, different kinds of drugs which suppress CNS.
Side effects:
Chloropyramineis anticholinergic properties and the fact that it can pass through the blood-brain barrier are linked to its clinical side effects: drowsiness, weakness, vertigo, fatigue, dryness in the mouth, constipation, and rarely - visual disturbances and increase of intraocular pressure.
Interactions:
with different inhibitors of MAO Strengthens action of the general anesthesia, soporific, sedative, opioid analgesics, local anesthetics. It is incompatible with ethanol. Strengthens action of Tricyclic antidepressants. Caffeine and phenamine decrease suppressing action of Suprastin on CNS.
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