![Diprospan (Betamethasone [Dipropionate + Sodium Phosphate ])](/images/B/diprospan-betamethasone-dipropionate-sodium-phosphate-.gif) Actual product may differ in
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Common name
Diprospan (Betamethasone [Dipropionate + Sodium Phosphate ])
Description
Betamethsone is a synthetic glucocorticoid, the most active of the anti-infalammatory steroids, used topically as an anti-infalmmatory and administered orally as a replacment therapy for adrenal insufficiency. Its derivative Betamethasone Dipropionate is a corticosteroid with mainly glucocorticocoid activity. It has slow but more prolonged actions. Betamethasone Dipropionate is used topically in the treatment of various skin disorders. Betamethasone Sodium Phosphate is a corticosteroid which is used topically or rectally as sodium phosphate as an antiinflammatory steroid. Betamethasone (Valerate) is the 17-valerate ester of betamethasone
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Therapeutic actions:
Synthetic, long-acting glucocorticoid that depresses formation, release, and activity of endogenous mediators of inflammation, including prostaglandins, kinins, histamine, liposomal enzymes, and complement system. Also modifies bodyis immune response.
Indications:
Systemic treatment of primary or secondary adrenal cortex insufficiency, rheumatic disorders, collagen diseases, dermatologic diseases, allergic states, allergic and inflammatory ophthalmic processes, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states (resulting from nephrotic syndrome), GI diseases, multiple sclerosis, tuberculous meningitis and trichinosis with neurologic or myocardial involvement. Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Contraindications:
Systemic fungal infections; IM use in idiopathic thrombocytopenic purpura; administration of live virus vaccines when patient is receiving immunosuppressive doses. Monotherapy in primary bacterial infections. Do not use on face, groin, or axilla or for ophthalmic treatments.
Cautions:
Pregnancy, Category C. Lactation, Excreted in breast milk, Growth and development of infants and children on prolonged therapy must be monitored, even with topical treatment. Elderly may require lower doses. Consider benefits relative to risks. Hypersensitivity Anaphylactoid reactions have occurred rarely. Adrenal suppression Prolonged therapy may lead to HPA suppression. Can cause elevated BP, salt and water retention, and increased potassium and calcium excretion. Dietary salt restriction and potassium supplementation may be necessary. Hepatitis May be harmful in chronic active hepatitis positive for hepatitis B surface antigen. Infections, may mask signs of infection. May decrease host-defense mechanisms. Ocular effects. Caution patient to discontinue medication and notify health care provider if affected area worsens or develops irritation, redness, burning, swelling, or stinging.
Side effects:
Cardiovascular
Thromboembolism or fat embolism; thrombophlebitis; necrotizing angiitis; cardiac arrhythmias or ECG changes; syncopal episodes; hypertension; myocardial rupture; CHF, CNS. Convulsions; increased intracranial pressure with papilledema (pseudotumor cerebri); vertigo; headache; neuritis/paresthesias; psychosis; fatigue; insomnia.
Dermatologic
Impaired wound healing; thin, fragile skin; petechiae and ecchymoses; erythema; lupus erythematosus–like lesions; suppression of skin test reactions; subcutaneous fat atrophy; purpura; striae; hirsutism; acneiform eruptions; allergic dermatitis; urticaria; angioneurotic edema; perineal irritation; hyperpigmentation; hypopigmentation.
Topical application may cause burning; itching; irritation; erythema; dryness; folliculitis; hypertrichosis; pruritus; perioral dermatitis; allergic contact dermatitis; numbness of fingers; stinging and cracking/tightening of skin; maceration of skin; secondary infections; skin atrophy; striae; miliaria; telangiectasia.
Pancreatitis; abdominal distension; ulcerative esophagitis; nausea; vomiting; increased appetite and weight gain; peptic ulcer with perforation and hemorrhage; small and large bowel perforation. Genitourinary, Increased or decreased motility and number of spermatozoa. Musculoskeletal (eg, weakness; myopathy; tendon rupture; osteoporosis; aseptic necrosis of femoral and humeral heads; spontaneous fractures, including vertebral compression fractures and pathologic fracture of long bones); hypersensitivity, including anaphylactic reactions; aggravation or masking of infections; malaise. Topical use may produce same adverse reactions seen with systemic use.
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