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Common name
Skinoren cream (Azelaic acid)
Synonyms: Azelex, Emerox, Finevin, Skinoderm
Description
Skinoren cream (Azelaic acid) attacks the bacteria, Propionibacterium acnes, that play an essential part in causing acne. Skinoren also reduces growth of the keratin surface cells that block the pores of the skin to cause blackheads and whiteheads.
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Active Ingredients:
Azelaic acid
Therapeutic actions:
The antimicrobial property of azelaic acid and a direct influence on follicular hyperkeratosis are assumed to be the basis for the therapeutic efficacy of Skinoren cream (Azelaic acid) in acne. Azelaic acid exerts an antibacterial effect on Propionibacterium acnes and causes a significant reduction of the colonisation density of Propionibacterium acnes. A significant reduction of the fraction of free fatty acids in the skin surface lipids also occurs. In animal experiments azelaic acid inhibits the proliferation of cultivated keratinocytes (suppression of DNA synthesis) and accelerates the comedolysis of tetradecane-induced comedones. After treatment with Skinoren Acne Cream ultrastructural changes in particular of the keratohyaline granules and of filaggrin, an important factor in keratinisation occurred. These findings suggest that, under clinical conditions, Skinoren Acne Cream affects the keratinocytes and the pattern of keratinisation. The amount of azelaic acid recovered in the viable epidermis and the corium increased with the time of exposure and was approximately 9,5% of the applied dose after 24 hours. Following topical application of 1 g azelaic acid (5 g Skinoren Acne Cream) to human volunteers 2,2% (+ 0,7%) of the dose was excreted as unchanged substance in the urine within 72 hours.
What is it used for?
Persen relieves the following signs of nervousness:
• irritability and agitation;
• emotional tension and anxiety;
• difficulty in concentration and memory disorders (stage fright and examination tremors);
• tiredness occurring immediately after getting up or after the slightest effort.
Indications:
Topical treatment of mild to moderate acne vulgaris.
Contraindications and cautions:
Do not take Presen:
• if you are hypersensitive to any of the ingredients.
• If you have arterial hypotension, peptic ulcer disease Tell your doctor if you are pregnant or breast-feeding.
Side effects:
Like all medicines, Persen can cause side effects, although not everybody gets them.
Very rare: - allergic reactions - undue fatiguability
Interactions:
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Please be careful if you take medicines which depress the central nervous system during use of Persen, as Persen may increase the effects of these medicines.
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