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Common name
Imigran (Sumatriptan)
Synonyms: Suminat, Imigran, Sumatran, Sumax
Description
Imigran works against migraines. Interaction with receptors, mainly in the brain blood vessels (their stimulation leads to a narrowing of vessels).
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Active Ingredients:
Sumatriptan succinate
Therapeutic actions:
Imigran belongs to a group of drugs called serotonin agonists. It works by making certain blood vessels in the head normal again and ease the symptoms of migraine.
What is it used for?
Imigran tablets are used to relieve headache and other symptoms of a migraine attack. They should not be used to prevent migraine attacks from occurring. Imigran tablets may be used for migraine headaches with or without what is known as iaurai. There is no information on the use of Imigran tablets in special kinds of migraine known as ibasilar migrainei or ihemiplegic migrainei. It is thought that migraine headache is due to widening of certain blood vessels in the head. Imigran tablets do not work in other types of headache which are not a migraine.
Contraindications and cautions:
Use with caution in:
• Allergy to medicines from the sulphonamide group, eg the antibiotic sulfamethoxazole.
• Controlled high blood pressure (hypertension).
• People with risk factors for ischaemic heart disease, such as smoking, high cholesterol levels, diabetes, obesity, or a family history of heart disease.
• Men over 40 years.
• Postmenopausal women.
• Decreased kidney function.
• Decreased liver function.
• History of seizures eg epilepsy.
Do not take Imigran tablets if you have ever had an allergic reaction to sumatriptan succinate or any of the ingredients.
Symptoms of an allergic reaction may be mild or severe. They usually include some or all of the following: wheezing, swelling of the lips/mouth, difficulty in breathing, hayfever, lumpy rash ("hives") or fainting.
Do not take Imigran tablets if you are pregnant, trying to become pregnant or breastfeeding, unless your doctor says you should.
Your doctor will discuss the risks and benefits of taking Imigran tablets if you are pregnant or breastfeeding.
Do not take Imigran tablets if you have or have had:
o heart disease, or previous heart attack.
o shortness of breath, pain or tightness in the chest, jaw or upper arm.
o Prinzmetalis angina. o angina, or severe chest pain or tightness.
o high blood pressure.
Do not take Imigran tablets if you have taken any of these medicines in the last 24 hours:
o Ergotamine containing preparations (for example, Cafergot)
o Methysergide (for example, Deseril)
Do not take Imigran tablets if you have taken Monoamine oxidase inhibitors (MAOIs), a type of medicine used for depression in the last two weeks.
Side effects:
Like other medicines, Imigran tablets can cause some side-effects. If they occur, they are most likely to be minor and temporary.
Tell your doctor at your next visit if you notice any of the following after taking Imigran tablets:
• pain, tingling, heat or flushing in any part of the body.
• feeling of sleepiness, dizziness or tiredness.
• nausea (feeling sick) or vomiting.
• a change in blood pressure.
• feeling of faintness.
• visual disturbances.
• shaking or tremors.
Tell your doctor immediately and do not take any more Imigran tablets if you:
• feel heaviness, pressure or tightness in any part of the body, including the chest or throat.
• feel abnormal heart beats - too fast, too slow, or irregular heart beats, palpitations.
• have a fit or convulsion.
Interactions:
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.
This medicine must not be taken at the same time as, or within two weeks of, taking a monoamine oxidase inhibitor (MAOI), for example, the antidepressants phenelzine, tranylcypromine, isocarboxazid and moclobemide, and the antibiotic linezolid. This is because these medicines could increase the blood level of sumatriptan and therefore increase the risk of side effects.
This medicine must not taken within 24 hours of taking ergotamine or its derivatives, eg dihydroergotamine or methysergide. These medicines should not be taken within six hours of taking sumatriptan. You should not take ergotamine, dihydroergotamine or methysergide for at least six hours after taking sumatriptan.
There may be an increased risk of a rare side effect called the serotonin syndrome if sumatriptan is taken in combination with other medicines that enhance the activity of serotonin in the central nervous system, such as the following:
• selective serotonin reuptake inhibitor antidepressants (SSRIs), such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine or sertraline
• serotonin noradrenaline reuptake inhibitors (SNRIs), such as venlafaxine or duloxetine
• the herbal remedy St Johnis wort (Hypericum perforatum).
If you are taking any of these medicines you should let your doctor know if you experience symptoms such as confusion, agitation, tremor, muscle twitching, shivering, sweating, racing heartbeat or diarrhoea after taking sumatriptan
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