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Common name
Danol (Danazol)
Description
Danol (Danazol) is a man-made form of a steroid. Danol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body.
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What is it used for?:
• Pain and/or infertility due to endometriosis;
• A tendency for females to develop cysts in the breasts (fibrocystic breast disease); or
• Hereditary angioedema, which causes swelling of the face, arms, legs, throat, windpipe, bowels, or sexual organs. Danazol may also be used for other conditions as determined by your doctor.
This medicine is available only with your doctoris prescription, in the following dosage form:
• Oral
• Capsules (U.S. and Canada)
Contradictions and cautions:
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.
For danazol, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to danazol, androgens (male hormones), or anabolic steroids. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Danazol is not recommended for use during pregnancy, since it may cause a female baby to develop certain male characteristics.
Breast-feeding—Breast-feeding is not recommended while you are taking this medicine because it may cause unwanted effects in the baby.
Children—Danazol may cause male-like changes in female children and cause premature sexual development in male children. It may also slow or stop growth in any child.
Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of danazol in the elderly with use in other age groups, danazol has effects similar to androgens (male hormones). Androgens used in older males may increase the risk of developing prostate enlargement or cancer.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking danazol, it is especially important that your health care professional know if you are taking any of the following:
• Anticoagulants (blood thinners)—Danazol may increase the effects of these medicines and possibly increase the risk of severe bleeding
• Tacrolimus (e.g., Prograf)—Danazol may increase the effects of tacrolimus by increasing the amount of that medicine in the body
Other medical problems—The presence of other medical problems may affect the use of danazol. Make sure you tell your doctor if you have any other medical problems, especially:
• Blood clotting disorders or
• Severe liver disease or
• Tumor caused by too much male hormones or
• Tumor on the genitals or
• Unusual bleeding from the vagina—Danazol should not be used when these conditions exist
• Porphyria—This condition may be made worse
• Type 2 diabetes mellitus—Danazol may increase blood glucose (sugar) levels
• Epilepsy or
• Heart disease or
• Kidney disease or
• Migraine headaches—These conditions can be made worse by the fluid retention (keeping too much body water) that can be caused by danazol
Side Effects :
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur:
For both females and males
Less common
Acne;
dark-colored urine; increased oiliness of hair or skin; muscle cramps or spasms; swelling of feet or lower legs; unusual tiredness or weakness; weight gain (rapid)
Rare
Bleeding gums; bloating, pain or tenderness of abdomen or stomach; blood in urine; burning, numbness, pain, or tingling in all fingers except the smallest finger; changes in vision; chest pain; chills; complete or partial numbness or weakness on one side of body; cough; coughing up blood; diarrhea; difficulty in speaking; difficulty in swallowing; discharge from nipple; eye pain; fast heartbeat; fever; headache; hives or other skin rash; joint pain; light-colored stools; loss of appetite (continuing); loss of muscle coordination; more frequent nosebleeds; muscle aches; nausea; purple- or red-colored, or other spots on body or inside the mouth or nose; restlessness; shortness of breath; sore throat; sweating; tingling, numbness, or weakness in legs, which may move upward to arms, trunk, or face; unusual bruising or bleeding; unusual tiredness, weakness, or general feeling of illness; vomiting; yellow eyes or skin
For females only
More common
Decrease in breast size; irregular menstrual periods; weight gain
Rare
Enlarged clitoris; hoarseness or deepening of voice; unnatural hair growth
For males only
Rare
Changes in semen; decrease in size of testicles Other side effects may occur that usually do not need medical attention.
These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
For both females and males
Less common
Flushing or redness of skin; mood or mental changes; nervousness
Rare
Increased sensitivity of skin to sunlight
For females only
Less common
Burning, dryness, or itching of vagina; vaginal bleeding Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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