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Common name
Neurobex (Vitamines B1-B6-B12)
Description
Used in combination drug Neurobeks Group B vitamins affects a number of processes occurring in the body. Vitamins that group are part of the enzymes catalyzing reactions of metabolism of carbohydrates, lipids and proteins. The combination of Group B vitamins in drug metabolism Neurobex (Vitamines B1-B6-B12) normalizes vegetative centers, education, transfer pulses and trofiku neyrotsitov, improves the functioning of nerve cells and subcortical centres, thus normalized vegeto-emotional state.
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Active ingredients:
Metamizole sodium (Amigin), Thiamine hydrochloride (Vitamin B1), Pyridoxine hydrochloride (Vitamin B6), Cyancobalamin (Vitamin B12).
Therapeutic action:
There is a combining preparation containing vitamins of B group which are parts of enzymes catalyzing the metabolite reactions of carbohydrates, fats and proteins.
Vitamin B1 lacks pharmacodynamic activity in therapeutic doses but it possesses various physiologic functions.
Vitamin B1 after absorption is transformed in the organism to thiamine pyrophosphate that is a coenzyme of enzymes which take part in the decarboxylation of pyruvic and a-ketoglutaric acid. Its lack leads to accumulation of lactic and pyruvic acid flint could provoke polyneuritis, beri-beri in case of avitaminosis and severe hypovitaminosis, Wernicke encephalopathy and Korsakoff syndrome, alcoholic polyneuropathy and disturbances of the heart function. Its daily absorption is limited from 8 to 15 mg. Toxic effect is seen after prolonged peception only. There are rarely cases of hypersensitivity.
Vitamin B6 has also a slight pharmacodynamic activity. The physiologic functions of Vitamin B6 and of its metabolite pyridoxaiphosphate as a coenzyme, include the integration in several metabolite transformations of the amino acids. It takes part in the transformation of 5-hydroxytryptamine, of methionine into cysteine. Deficiency of Vitamin B6 could develop in insufficient nutritional supply, disturbed intestinal absorption reception of drugs which are its antagonists, radiotherapy. The symptoms of deficiency are manifested with seborrhea like lesions around eyes, nose, glossitis, stomatitis; peripheral neuritis, seizures, anemia.
Vitamin B12 does not exert pharmacodynamic activity. The psychological significance of the active coenzymes methylobalamin and 5-deoxyadenosincobalamin is essential for the cellular growth and replication. It participates in the processes of transmethylation and transportation of hydrogen cations in the synthesis of choline, methionine, creatinine and nucleic acids. It takes an important part in the processes of hemopoesis. It exerts favourable activity on the function of liver and nervous system. The Vitamin B12 lack is manifested with symphoms of the side hemopoietic and nervous system.
Indications:
Neurobex (Vitamines B1-B6-B12) is administered as a part of combined therapy in: neurites, polyneurites (alcoholic postinfecious, toxic, diabetic polyneuritis). neuralgies, lumbago, radiculitis, chorea, paresthesias, myasthenia, spasmodic states of central origin, atherasclercsis, diabetes, chronic alcoholism, asthenia; dermatitis, exemas, psoriasis, exudative diathesis, acne.
Contraindications and Cautions:
Allergy to vitamins of B group, acute thromboembolism, erythrosis and erythremia.
Vitamin B6 decreases the antiparkinsonic effect of L-dopa. The metabolism of Vitamin B6 is disturbed in concomitant administration with oral contraceptives. Vitamin B6 antagonists are: isoniazid, penicillamine, cycloserine, thiosemicarbazones (the effects are ithibited).
It should S carefully applied in angina pectoris. Neurotoxicity with slight manifestation of dependence could be provoked in prolonged reception of 200mg Vitamin B6.
It is not contraindicated but in pregnant women arid nursing mothers the optimal feeding regimen and sufficient supply of vitamins with meal is recommended.
There are no data about unfavorable influence on the active attention, reflexes and motor activity
Side effects:
Allergic reactions. In high doses: nervous excitement, tachycardia, pains in the heart area.
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