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Common name
Glibomet (glibenclamide and metformine)
Description
Glibomet ® (Glyburide and Metformin HCl Tablets) contains two oral antihyperglycemic drugs used in the management of type 2 diabetes, glyburide and metformin hydrochloride. Glyburide and metformin both are oral Diabetes medicine. They are used to control the sugar levels in the blood. Mixture of this drugs have proved to be more potent then the drugs alone.
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Active Ingredients:
Glibenclamide and metformine
Therapeutic actions:
Glibomet combines glyburide and metformin hydrochloride, two antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with type 2 diabetes. Glyburide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which glyburide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in patients with type 2 diabetes, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs. Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
What is it used for?: (Indications:)
Glibomet is used to treat uncontrolled non insulin dependent diabetes which is not responding to biguadine and sulphonylureas therapy. Glibomet in other words is used for people with diabetes type 2.
Contraindications and cautions:
If you are taking Glibomet (glyburide and metformine) a life threatening condition called lactic-acidosis can develop. You should get immediate help if any of the following symptoms start to manifest: Increasing sleepiness, cold feeling, weakness, slow heart rate, muscle pain, shortness of breath, stomach pain, lightheadedness or fainting. If you suffer form congestive heart failure, kidney disease, liver disease, or you are in a state of diabetic ketocaidosis be sure to consult your local health care professional before using Glibomet and may need a dosage adjustment. Glibomet is in the pregnancy category B. Consult your doctor regarding the use of Glibomet if you are pregnant, planning to become pregnant or breastfeeding a baby. All the information regarding individual risk of Glibomet usage can be acquired at your local health care professional.
Side effects:
There are possible side-effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using Glibomet will experience it or any other. Stop using Glibomet and call your doctor as son as possible if any of the following symptoms start to manifest: Hives, difficulty breathing, swelling, short breath or mild exertion, rapid weight gain.
Other less serious side effects are:
• Headache
• sneezing, cough, signs of a cold
• mild nausea, vomiting, stomach pain , diarrhea
• dizziness
The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with Glibomet, please read the information provided with this drug or consult your doctor or pharmacist.
Interactions:
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Glibomet. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe. Be sure not to mix glyburide and metformin with other drugs which raise or lower your blood sugar because of the possibility to increase their effectiveness.
Interactions with Glibomet have been shown by the following medicine:
• morphine
• ciprofloxacin
• furosemide
• quinidine
• trimethoprim
• cimetidine or ranitidine
• nifedipine
• vancomycin
• amiloride or triamterene
• procainamide
• digoxin
If any of this drugs are used by you then you may need a dosage adjustment or special monitoring during treatment.
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