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Common name
Lantus (insulin glargine [rDNA origin] injection)
Description
LANTUS® (insulin glargine [rDNA origin] injection) is a sterile solution of insulin glargine for use as an injection. Insulin glargine is a recombinant human insulin analog that is a long-acting (up to 24-hour duration of action), parenteral blood-glucose-lowering agent. LANTUS is produced by recombinant DNA technology utilizing a non- pathogenic laboratory strain of Escherichia coli (K12) as the production organism. Insulin glargine differs from human insulin in that the amino acid asparagine at position A21 is replaced by glycine and two arginines are added to the C-terminus of the B-chain.
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Active Ingredients:
insulin glargine [rDNA origin] injection
Therapeutic actions:
Lantus is a long-acting insulin analog that helps the body regulate the removal of glucose from the bloodstream. It is the first analog with a 24-hour glucose lowering effect with no pronounced peak of action, providing a continuous, steady release.
What is it used for?:
(Indications:)
Lantus is indicated for once-daily subcutaneous administration at bedtime in the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.
Contraindications and cautions:
LANTUS is contraindicated in patients hypersensitive to insulin glargine or the excipients. • This medicine is not recommended for children under six years of age.
• This medicine must not be injected into a vein (intravenously).
• Your insulin requirements may increase when you are ill, especially if you have an infection or fever.
• People with diabetes who are on insulin should only drink alcohol in moderation and accompanied by food.
• Your ability to concentrate or react may be reduced if you have low blood sugar, and this can cause problems driving or operating machinary. You should take precautions to avoid low blood sugar when driving - discuss this with your doctor.
• Low blood sugar (hypoglycaemia) can occur as a side effect of insulin therapy.
Side effects:
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
• Allergic reaction to active ingredient
• Low blood glucose level (hypoglycaemia)
• Pain at injection site
• Excessive fluid retention in the body tissues, resulting in swelling (oedema)
• Skin thickening or pitting (lipodystrophy) if injection given too frequently into the same site
• Redness, swelling or itching at the injection site
• Nausea
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
Interactions:
Tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.
The following medicines may decrease blood sugar levels and people taking these medicines may therefore need a decrease in their insulin dose:
• antidiabetic medicines taken by mouth
• octreotide
• disopyramide
• fibrates for high cholesterol levels, eg bezafibrate
• anabolic steroids, eg testosterone, nandrolone, stanozolol
• ACE inhibitors, eg captopril (these can cause unpredictable drops in blood sugar)
• MAOI antidepressants, eg phenelzine
• fluoxetine
• large doses of salicylates, eg aspirin (small pain relieving doses do not normally have this effect).
The following medicines may increase blood glucose levels and people taking these may need increased doses of insulin:
• corticosteroids, eg hydrocortisone, prednisolone
• diuretics, especially thiazide diuretics, eg bendrofluazide
• danazol
• diazoxide
• isoniazid
• some antipsychotic medicines, eg chlorpromazine
• somatropin (human growth hormone)
• lithium.
Oestrogens and progesterones, such as those contained in oral contraceptives, may affect blood sugar levels, and women taking these may need small adjustments up or down in their insulin dose.
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