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Common name
Myleran (busulfan)
Description
Myleran belongs to a group of medicines called cytotoxics. It works by reducing the amount of certain types of blood cells in your body.
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Active Ingredients:
Busulfan
Therapeutic actions:
The active ingredients of Myleran- Busulfan belongs to a group of anti cancer medication called alkylating agents. Busulfan works by slowing the process when the body's cells begin to multiply abnormally. It enters the cells and damage the genetic material. Busulfan also affects normal cells thus causing many possible side-affects during long-term treatment.
What is it used for?: (Indications:)
It is used to treat certain blood disorders. Myleran is used to treat the following conditions:
• Chronic myeloleukemia
• Erythremiya
• True polycythemia
• Trombocytopenia
• Myelofibrosis
It may also be used to prepare you for a procedure known as haematopoietic progenitor cell transplantation.
Contraindications and cautions:
You should not use this medication:
• If you have allergy to Myleran
• In pregnancy
• In breastfeeding
• Insufficient production of blood cell by the bone marrow
• Blood diseases(trombocytopenia, pancytopenia)
• Condition after chemotherapy
• High blood uric acid level
• In children
Warning!
• You should use Myleran under your health care provider supervision.
• Myleran should not be taken while receiving radiotherapy for the treatment of cancer.
• Your health care provider should control your blood levels while taking Myleran
Side effects:
Myleran works by reducing the number of new blood cells being made. Your doctor will do regular blood tests to check your blood cell levels. However, tell your doctor immediately if you notice any signs of fever or infection, or any unexpected bruising or bleeding, as this could mean that too few blood cells of a particular type are being produced.
Contact your doctor immediately if any of the following side effects occur:
The very common side effects of Myleran that have been reported in more than 1 in 10 people taking it include:
• reduction in number of white blood cells and platelets (which may affect clotting of blood)
• feeling sick, being sick, diarrhoea and mouth ulcers
• jaundice (yellowing of the whites of the eyes or skin)
• in women, periods may stop and fertility may be affected
• in girls, the onset of puberty may be delayed or prevented
• in boys and men, sperm production may be delayed, prevented, reduced or stopped.
Common side effects have been reported in between 1 in 10 and 1 in 100 people include:
• breathlessness due to heart not being able to beat properly, especially if you have thalassaemia
• pneumonia
• hair loss and appearance of patches of dark skin
• signs of blood in your urine and cystitis (pain when passing water)
• leukaemia.
Uncommon side effects reported in between 1 in 100 and 1 in 1,000 people taking Myleran include:
• in women, periods may stop and fertility may be affected Rare side effects reported in between 1 in 1,000 and 1 in 10.000 people include:
• anaemia
• fits
• cateracts or other eye problems
• nausea, vomiting, diarrhoea and mouth ulcers
• jaundice (yellowing of the whites of the eyes or skin) and liver problems
• hair loss, dry mouth and lips or any changes to your skin for example excessive dryness, itching, rash or darker areas of skin pigmentation.
Very rare side effects reported in less than 1 in 10,000 people taking Myleran include:
• muscle weakness
• enlargement of breasts in male patients
• weakness, feeling tired, weight loss, feeling sick, being sick and dark skin patches.
If you are taking higher doses of Myleran the side effects may be worse. Ask your doctor for details.
Interactions:
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Myleran. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe.
• The risk of possible side effects increases while combination use of Myleran and tioguanine.
• Myleran may reduce the efficacy of certain vaccines.
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