Active Ingredients:
Cytisine

Other ingredients:
Calcium dihydrogenphosphate, Lactose, Wheat starch, Microcrystalline cellulose, Talc, Magnesium stearate. Pharmaco-therapeutic group: Vegetotropic agent - N- cholinomimetic (gangliostimulant).

Therapeutic actions:
The preparation Tabex, developed on the basis of cytisine, possesses a similar mechanism of action like that of nicotine. Tabex (Cytisine) plays the role of nicotine substitution substance, and reduces the period of interaction of the received nicotine with relevant nicotine receptors, i.e. the specific substance cytisine "substitutes" nicotine, acting on the same receptors, thus preventing the appearance of abstinence syndrome. This results in a gradual reduction and suspension of the psychic and physical dependency to nicotine in smokers.

What is it used for?:
( Indications:)
Chronic nicotinism (tabacosis) - for breaking the habit of smoking. Contraindications and cautions: Tabex (Cytisine) is contraindicated in arterial hypertension and advanced atherosclerosis.

Side effects:
Tabex is considered safe and induces no changes in the physchophysical status, driving ability and machine operation. Clinical studies showed a good tolerance to the drug and grave adverse effects were not observed. The following adverse effects are rather often observed at the beginning of Tabex treatment: changes in both taste and appetite, dryness in the mouth, headache, irritability, nausea, constipation, tachycardia, light elevation of the arterial pressure. The majority of the adverse effects can abate in the course of the treatment.

Possible Side Effects

The scientific studies have demonstrated a reasonable tolerance and a string of mild side effects. Here is a list of side effects - altered appetite and taste, nausea, headache, dryness of mouth, irritability, constipation, abnormal heart beats and increase of arterial pressure albeit slightly. It must be noted that most of the side effects fade out during the course of the treatment.

However, the extent of side effects of Tabex to patients with cardiac impairment, ischemic heart disease, obliterating arterial & cerebrovascular troubles, renal and hepatic deficiency, hyperthyroidism and diabetes are not adequately tested and documented clinically.

Pregnancy and Lactation: pregnant women are advised against using the drug in case of unrestrained administration. Like wise, the Tabex is also not recommended for breast feeding mothers as cystisine is proven to possess the ability to enter into breast milk.

Interactions with Other Drugs

As clinical tests are still inconclusive, enough data of either positive or adverse interaction of Tabex with other drugs is still not available.

Overdose

Overdose of Tabex is observed to cause nicotine intoxication symptoms and its toxic effects manifested into dilation of pupil, abnormal heartbeats, vomiting, nausea, headache, paralysis of respiration and colonic convulsions. Usual line of action in such cases is one of monitoring of respiration, irrigation of the stomach, arterial pressure and initiation of heart rate as is the normal practice in all overdose cases.