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Common name
Unasyn Oral (sultamicillin tosylate)
Synonyms: Unasyn, Oral
Description
Ampicillin and sulbactam are antibiotics in the penicillin group of drugs. Unasyn Oral (sultamicillin tosylate) - this combination is used to treat many different types of infections caused by bacteria.
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Active Ingredients:
sultamicillin tosylate
Therapeutic actions:
The addition of sulbactam, a beta-lactamase inhibitor, to ampicillin extends the spectrum of ampicillin to include some beta-lactamase producing organisms; inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
What is it used for?:
• Skin and Skin Structure Infections;
• Intra-Abdominal Infections;
• Gynecological Infections.
Contraindications and cautions:
• allergy to any ingredient in Unasyn or any other penicillin antibiotic (eg, amoxicillin);
• taking a tetracycline antibiotic (eg, doxycycline);
• mononucleosis;
• caution if EBV, CMV infection;
• caution if ALL;
• caution if hypersens. to cephalosporins;
• caution if impaired renal fxn;
• caution if hyperuricemia;
Side effects:
Serious side effects: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); vein inflammation or tenderness; chest pain; severe nausea or vomiting; stomach pain or cramps; chills; unusual bruising or bleeding; bloody or severe diarrhea; vaginal irritation or discharge; fever; white patches in mouth.
Less serious side effects: diarrhea; pain, swelling, or redness at injection site.
Interactions:
• Unasyn is effectiveness may be decreased by tetracyclines (eg, doxycycline);
• Allopurinol may increase the risk of skin rash;
• Heparin may increase the risk of bleeding;
• Unasyn Oral (sultamicillin tosylate) may increase the risk of side effects of methotrexate;
• Unasyn Oral (sultamicillin tosylate) may decrease effectiveness or increase the risk of their side effects of anticoagulants (eg, warfarin);
• Unasyn Oral (sultamicillin tosylate) may decrease effectiveness of aminoglycosides (eg, gentamicin) or oral contraceptives (eg, ethinyl estradiol/norethindrone).
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