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Common name
Bactrim (Sulfamethoxazole / Trimethoprim)
Description
Bactrim (Sulfamethoxazole / Trimethoprim) is used to treat ear infections, urinary tract infections, bronchitis, traveler is diarrhea, and Pneumocystis carinii pneumonia.
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Active Ingredients:
Sulfamethoxazole / Trimethoprim
Therapeutic actions:
Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para -aminobenzoic acid (PABA). Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. Thus, Bactrim blocks two consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria. In vitro studies have shown that bacterial resistance develops more slowly with Bactrim than with either trimethoprim or sulfamethoxazole alone.
What is it used for?:
Sulfamethoxazole and trimethoprim is used to treat infections such as urinary tract infections, bronchitis, ear infections (otitis), traveleris diarrhea, and Pneumocystis carinii pneumonia.
Contraindications and cautions:
• allergy to any ingredient in Bactrim or to similar medicines;
• severe allergic reaction to any other sulfonamide (sulfa) medicine (eg, glipizide, hydrochlorothiazide);
• taking dofetilide;
• anemia caused by low levels of folate in the blood or urinary blockage;
• 38 week of pregnancy or later (full-term) or breast-feeding;
• Children younger than 2 months old.
Side effects:
Less serious: appetite loss; nausea; vomiting.
Serious: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistered, peeling, red, or swollen skin; bloody or black, tarry stools; chest pain; chills, fever, or sore throat; unusual bruising or bleeding; depression; hallucinations; irregular heartbeat; vaginal irritation or discharge; unusually pale skin; joint or muscle pain; painful or stiff neck; purple patches under the skin; seizures; severe diarrhea; severe or persistent cough; decreased urination; severe or persistent headache; severe or persistent nausea or vomiting; shortness of breath; stomach cramps/pain; unusual tiredness or weakness; yellowing of the skin or eyes.
Interactions:
• Bactrim is effectiveness may be decreased by Leucovorin;
• the risk of Bactrim is side effects may be increased by angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, hydrochlorothiazide);
• Anticoagulants (eg, warfarin) may increase the risk of bleeding;
• Dofetilide may increase the risk of severe heart problems;
• Bactrim may increase the risk of side effects of digoxin, methotrexate, phenytoin, sulfones (eg, dapsone), or sulfonylureas (eg, glipizide);
• effectiveness of cyclosporine may be decreased and the risk of liver side effects may be increased
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Bactrim brands
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Product |
Manufacturer |
Price |
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Biseptam
100 capsules (480 mg/capsule)
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Tamuspharm, Romania |
$39.00 |
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Biseptol
20 tablets (120 mg/tablet)
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Pharmaceutical Works Polfa in Pabianice |
$5.00 |
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Biseptol
suspension (80 ml)
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Polpharma, Poland |
$9.00 |
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Biseptol,
20 tablets (480 mg/tablet)
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Pharmaceutical Works Polfa in Pabianice |
$10.00 |
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