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Common name
Accupro (Quinapril)
Description
Quinapril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Quinapril is used to treat high blood pressure (hypertension) and heart failure.
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Active Ingredients:
Quinapril
Therapeutic actions:
Quinapril is an angiotensin-converting enzyme (ACE) inhibitor. ACE is involved in certain chemical reactions that constrict (narrow) blood vessels and cause sodium and fluid retention by the kidney. This can cause an increase in blood pressure. ACE inhibitors lower elevated blood pressure by interfering with ACE and cause blood vessels to relax (widen). Blood flows more freely and at a lower pressure. ACE inhibitors also increase the heartis ability to pump blood in some types of heart failure.
What is it used for?:
Lowering high blood pressure and managing heart failure.
Contraindications and cautions:
• allergy to any ingredient in Quinapril;
• the second or third trimester of pregnancy;
• previous angioedema (swelling of the face, lips, throat, or tongue) caused by treatment with an ACE inhibitor;
• Impaired renal and liver function.
Side effects:
Serious side effects: severe allergic reactions (rash; hives; itching; difficulty swallowing or breathing; difficulty breathing; irregular or slow heartbeat; tightness in the chest; chest pain; fainting; hoarseness; infection (sore throat, fever); shortness of breath; unusual stomach pain; swelling of the mouth, face, lips, or tongue); yellowing of the skin or eyes.
Less serious side effects: chest pain; coughing; diarrhea; difficulty breathing; dizziness; headache; lightheadedness; nausea; persistent, dry cough; tiredness; vomiting.
Interactions:
• Accupro is effectiveness may be decreased by nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) or salicylates (eg, aspirin);
• side effects, such as low blood pressure or increased potassium levels leading to heart attack, may be provoken by clozapine, cyclosporine, dextran sulfate, HMG-CoA reductase inhibitors (eg, simvastatin), mannitol, NSAIDs (eg, ibuprofen, indomethacin), pergolide, phenothiazines (eg, thioridazine), potassium preparations, potassium-sparing diuretics (eg, spironolactone), thiazide diuretics (eg, hydrochlorothiazide), or trimethoprim;
• Accupro may increase the risk of side effects of clozapine, iron salts (eg, ferrous sulfate), lithium, NSAIDs (eg, ibuprofen, indomethacin), potassium preparations, potassium-sparing diuretics (eg, spironolactone), sulfonylureas (eg, glipizide), thiazide diuretics (eg, hydrochlorothiazide), or thiopurines (eg, azathioprine).
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