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Common name
Cordarone (Amiodarone)
Description
Amiodarone is an antiarrhythmic medication that affects the rhythm of heartbeats. Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat ventricular tachycardia or ventricular fibrillation.
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Active Ingredients:
Amiodarone
Therapeutic actions:
Cordarone is an antiarrhythmic. It works by stabilizing the heart rhythm in conditions in which the heart is beating too fast or in an irregular rhythm. It is usually used in situations in which the abnormal heart rhythms, if not treated, could cause death.
What is it used for?:
Cordarone is indicated only for the treatment of the following documented, life-threatening recurrent ventricular arrhythmias when these have not responded to documented adequate doses of other available antiarrhythmics or when alternative agents could not be tolerated.
• Recurrent ventricular fibrillation.
• Recurrent hemodynamically unstable ventricular tachycardia.
Contraindications and cautions:
• allergy to any ingredient in Cordarone , including iodine;
• complete, second degree, third degree, or severe sinoatrial heart block; an abnormally slow heartbeat; or shock due to serious heart problems; or previous fainting due to slow heartbeat (except if you have a pacemaker);
• taking cisapride, dofetilide, an H1 antagonist (eg, astemizole, loratadine, terfenadine), an HIV protease inhibitor (eg, ritonavir), a phosphodiesterase type 5 inhibitors (eg, vardenafil), or a streptogramin (eg, dalfopristin, quinupristin).
Side effects:
Serious side effects: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; chills; coldness; cough; coughing up blood; dark urine; easy bruising or bleeding; enlarged thyroid gland; skin reaction similar to serious sunburn; eye discomfort; irregular pulse; shortness of breath; loss of coordination; muscle pain, tenderness, or weakness (especially with fever or unusual tiredness); nervousness; persistent sore throat; severe dizziness; severe stomach pain; slow heartbeat; sluggishness; decreased urination; sweating; tingling or numbness of hands or feet; fatigue; fever; uncontrolled shaking or tremor; unexplained weight change; menstrual changes; vision changes (seeing halos, blurred vision, loss of vision); wheezing; worsening of irregular heartbeat; yellowing of the skin or eyes.
Less serious side effects: abnormal skin sensations (loss of sensation; tingling; numbness; prickling); bitter taste in mouth; blue-green discoloring of skin (especially hands or feet); general body discomfort; constipation; trouble sleeping; decreased sexual interest; dizziness; dry eyes; flushing of the face; headache; involuntary muscle movements; loss of appetite; nausea; poor coordination; tiredness; vomiting.
Interactions:
• Cordarone is effectiveness may be decreased by cholestyramine, hydantoins (eg, phenytoin), rifampin, or St. Johnis wort;
• side effects, such as heart rhythm problems or seizures, may be provoken by antiarrhythmics (eg, flecainide), arsenic, azole antifungals (eg, ketoconazole), cimetidine, cisapride, diuretics (eg, furosemide, hydrochlorothiazide), dofetilide, droperidol, H1 antagonists (eg, astemizole, loratadine, terfenadine), HIV protease inhibitors (eg, ritonavir), ketolides (eg, telithromycin), macrolide antibiotics (eg, erythromycin), phenothiazines (eg, thioridazine), phosphodiesterase type 5 inhibitors (eg, vardenafil), pimozide, quinolones (eg, ciprofloxacin), serotonin receptor antagonists (eg, dolasetron), streptogramins (eg, dalfopristin, quinupristin), trazodone, or ziprasidone;
• low blood pressure, slow heartbeat, and other heart problems may be provoken by narcotic pain relievers (eg, fentanyl);
• Cordarone may increase the risk of side effects of anticoagulants (eg, warfarin), beta-blockers (eg, propranolol), calcium channel blockers (eg, verapamil, diltiazem), cyclosporine, dextromethorphan, digoxin, HMG-CoA reductase inhibitors (eg, simvastatin), lidocaine, or methotrexate;
• Cordarone may decrease effectiveness or may increase the risk of side effects of thyroid hormones (eg, levothyroxine);
• Cordarone may decrease effectiveness of clopidogrel.
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Cordarone brands
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Product |
Manufacturer |
Price |
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Amiodarona LPH
30 tablets (200 mg/tablet)
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LaborMed Pharma, Romania |
$16.00 |
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Amiokordin
30 tablets (200 mg/tablet)
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KRKA, Slovenia |
$14.00 |
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Amiokordin
60 tablets (200 mg/tablet)
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KRKA, Slovenia |
$26.00 |
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Amiokordin inj.
5 ampoules 3 ml (150 mg/5ml)
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KRKA, Slovenia |
$14.00 |
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Cordarone
30 tablets (200 mg/tablet)
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Sanofi-Aventis, France |
$24.00 |
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Cordarone inj.
6 ampoules 3 ml (150 mg/5ml)
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Sanofi-Aventis, France |
$24.00 |
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Miacardin
30 tablets (200 mg/tablet)
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New Tone, Romania |
$14.00 |
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