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Common name
Calan (Verapamil)
Description
Verapamil relaxes (widens) blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload. It is used to treat hypertension (high blood pressure), to treat angina (chest pain), and to control some types of irregular heartbeats.
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Active Ingredients:
Verapamil
Therapeutic actions:
Calan is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and contractile myocardial cells.
What is it used for?:
• Treating supraventricular tachycardia, a rhythm disturbance of the heart.
• Controlling heart rate response to other rhythm disturbances, specifically atrial fibrillation and atrial flutte.
Contraindications and cautions:
• allergy to any ingredient in Calan;
• certain heart conditions (eg, sick sinus syndrome or second- or third-degree heart block and do not have a pacemaker) or very low blood pressure;
• atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart) such as Wolff-Parkinson-White syndrome (WPW) or Lown-Ganong-Levine syndrome (LGL);
• taking dofetilide or eletriptan.
Side effects:
Serious side effects: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); lightheadedness, especially upon standing; severe dizziness; swelling of feet or hands; shortness of breath; chest pain; unusually fast, slow or irregular heartbeat.
Less serious side effects: dizziness; fatigue; headache; lightheadedness.
Interactions:
• the actions and side effects of Calan, some potentially life-threatening, may be increased by beta-blockers (eg, propranolol), disopyramide, ketolides (eg, telithromycin), or macrolides (eg, erythromycin);
• Calan is effectiveness may br decreased by Rifampin;
• Calan may increase the actions and side effects, some potentially life-threatening of aldosterone blockers (eg, spironolactone), beta-blockers (eg, propranolol), carbamazepine, digoxin, dofetilide, eletriptan, erythromycin, flecainide, HMG-CoA reductase inhibitors (eg, simvastatin), lithium, nondepolarizing muscle relaxants (eg, atracurium), quinazolines (eg, metolazone), quinidine, or theophyllines (eg, aminophylline).
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