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Common name
Trental (Pentoxifylline)
Description
Trental is a medication that reduces the viscosity or "stickiness" of your blood, allowing it to flow more freely. It helps relieve the painful leg cramps caused by "intermittent claudication," a condition that results when hardening of the arteries reduces the leg musclesi blood supply.
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Active ingredient:
Pentoxifylline
Therapeutic action:
Some doctors also prescribe Trental for dementia, strokes, circulatory and nerve problems caused by diabetes, and Raynaudis syndrome (a disorder of the blood vessels in which exposure to cold causes the fingers and toes to turn white). The drug is also used to treat impotence and to increase sperm motility in infertile men.
Side effects:
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Trental. Trentalis side effects are fairly uncommon. More common side effects may include: Allergic reaction (symptoms include: swelling of face, lips, tongue, throat, arms, or legs, sore throat, fever and chills, difficulty swallowing, chest pain), anxiety, bad taste in the mouth, blind spot in vision, blurred vision, brittle fingernails, chest pain (sometimes crushing), confusion, conjunctivitis (pinkeye), constipation, depression, difficult or labored breathing, dizziness, dry mouth/thirst, earache, excessive salivation, flu-like symptoms, fluid retention, general body discomfort, headache, hives, indigestion, inflammation of the gallbladder, itching, laryngitis, loss of appetite, low blood pressure, nosebleeds, rash, seizures, sore throat/swollen neck glands, stuffy nose, tremor, vomiting, weight change
Contraindications and Cautions:
Do not take Trental if you have recently had a stroke or bleeding in the retina of your eye. If you are sensitive to or have ever had an allergic reaction to Trental, caffeine, theophylline (medication for asthma or other breathing disorders), or theobromine, do not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced. If you are taking a blood thinner, or have recently had surgery, peptic ulcers, or other disorders that involve bleeding, the doctor should test your blood periodically. Most people tolerate Trental well, but there have been occasional cases of crushing chest pain, low blood pressure, and irregular heartbeat in people with heart disease and brain disorders.
Interactions:
If Trental is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Trental with the following: Blood pressure medications such as Vasotec and Cardizem SR Blood-thinning drugs such as Coumadin Clot inhibitors such as Persantine Theophylline (Theo-Dur) Ulcer medicines such as Tagamet The effects of Trental during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Trental appears in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with this medication is finished.
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