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Common name
Persantine (Dipyridamole)
Description
Persantine (Dipyridamole) keeps the platelets in blood from clotting to prevent blood clots from forming on or around an artificial heart valve.
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Active Ingredients:
Dipyridamole
Therapeutic actions:
Persantine (Dipyridamole) inhibits the cellular reuptake of adenosine into platelets, red blood cells and endothelial cells leading to increased extracellular concentrations of adenosine. It also inhibits the enzyme adenosine deaminase which normally breaks down adenosine into inosine. This inhibition leads to further increased levels of extracellular adenosine. Dipyridamole prevents the enzyme phosphodiesterase- 5 (PDE 5) which normally breaks down cGMP. This results in added benefit when given together with NO or statins.
What is it used for?:
Persantine (dipyridamole USP) is indicated as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement.
Contraindications and cautions:
Do not use this medication if you are allergic to dipyridamole.
Before taking dipyridamole, tell your doctor if you are allergic to any drugs, or if you have:
• liver disease;
• low blood pressure;
• severe coronary artery disease (also called atherosclerosis);
• uncontrolled chest pain (angina); or
• if you have recently had a heart attack.
Side effects:
• hives;
• difficulty breathing;
• swelling of your face, lips, tongue, or throat.
Serious side effects:
• nosebleed or other bleeding that will not stop;
• black, bloody, or tarry stools;
• coughing up blood or vomit that looks like coffee grounds.
Less serious side effects may include:
• dizziness;
• upset stomach, diarrhea, vomiting;
• warmth, redness, or tingly feeling under your skin;
• muscle or joint pain;
• headache; or
• mild skin rash or itching.
Interactions:
No pharmacokinetic drug-drug interaction studies were conducted with Persantine.
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