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Common name
Fareston (toremifene)
Description
Fareston is an antiestrogen. It works by blocking the effects of estrogen on certain body tissues, including breast tissue. This helps block the growth of estrogen-activated tumors.
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Active Ingredients:
Toremifene
Therapeutic actions:
Toremifene is a nonsteroidal triphenylethylene derivative. Toremifene binds to estrogen receptors and may exert estrogenic, antiestrogenic, or both activities, depending upon the duration of treatment, animal species, gender, target organ, or endpoint selected. The antitumor effect of toremifene in breast cancer is believed to be mainly due to its antiestrogenic effects, i.e., its ability to compete with estrogen for binding sites in the cancer, blocking the growth-stimulating effects of estrogen in the tumor.
Toremifene causes a decrease in the estradiol-induced vaginal cornification index in some postmenopausal women, indicative of its antiestrogenic activity. Toremifene also has estrogenic activity as shown by decreases in serum gonadotropin concentration (FSH and LH).
What is it used for?:
Metastatic breast cancer in postmenopausal women.
Contraindications and cautions:
Pregnancy and breast-feeding.
Side effects:
Serious side effects:
• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
• constipation, loss of appetite, nausea, vomiting, and severe stomach pain, which may be caused by hypercalcemia (excess calcium in the blood);
• pain, redness, or warmth in an arm or leg (may indicate a blood clot);
• chest pain;
• blurred vision; or
• vaginal bleeding.
Other:
• hot flashes;
• sweating; or
• vaginal discharge.
Interactions:
Be cautious if taking the following drugs together with Fareston:
• an anticoagulant such as warfarin (Coumadin);
• a thiazide diuretic (water pill) such as chlorothiazide (Diurigen, Diuril), chlorthalidone (Hygroton, Thalitone), hydrochlorothiazide (HydroDiuril, Esidrix, Microzide, others), indapamide (Lozol), or metolazone (Diulo, Mykrox, Zaroxolyn); or
• a seizure medication such as carbamazepine (Tegretol), ethosuximide (Zarontin), or phenytoin (Dilantin)
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