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Common name
Bromocriptin (Bromocriptine)
Description
Bromocriptineinhibits the secretion of the hormone prolactin from the pituitary gland. It also mimics the action of dopamine, a chemical lacking in the brain of someone with Parkinson's disease.
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Active Ingredients:
Bromocriptine
Therapeutic actions:
Bromocriptin is a dopamine receptor agonist, which activates post-synaptic dopamine receptors. The dopaminergic neurons in the tuberoinfundibular process modulate the secretion of prolactin from the anterior pituitary by secreting a prolactin inhibitory factor; in the corpus striatum the dopaminergic neurons are involved in the control of motor function. Clinically, Bromocriptin significantly reduces plasma levels of prolactin in patients with physiologically elevated prolactin as well as in patients with hyperprolactinemia. The inhibition of physiological lactation as well as galactorrhea in pathological hyperprolactinemic states is obtained at dose levels that do not affect secretion of other tropic hormones from the anterior pituitary.
What is it used for?:
Treating Parkinson disease, certain conditions caused by too much prolactin in the blood (eg, excessive or abnormal breast milk production), certain menstrual problems, or abnormally large growth of certain body parts (acromegaly).
Contraindications and cautions:
• High blood pressure that is not under control
• pregnancy
• allergy to Bromocriptin or to any other drugs containing ergot alkaloids, such as Bellergal-S and Cafergot.
• Women who have severe heart conditions should not use Bromocriptin after they have had a baby unless it is medically necessary.
Side effects:
Allergic reaction: difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives.
Other: mild nausea, vomiting, or abdominal cramps; diarrhea or constipation; headache, dizziness (especially when rising from a sitting or lying position), or drowsiness; dry mouth; nasal stuffiness.
Interactions:
• Sumatriptan may cause excessive increases in blood pressure.
• Beta-blockers (eg, propranolol), sympathomimetics (eg, albuterol, amphetamine, pseudoephedrine), ergot alkaloids (eg, ergotamine), HIV protease inhibitors (eg, ritonavir), ketolides (eg, telithromycin), macrolides (eg, erythromycin), medicine for high blood pressure, or NNRT inhibitors (eg, efavirenz) increase the risk of side effects of Bromocriptin.
• Phenothiazines (eg, chlorpromazine), haloperidol, metoclopramide, or pimozide decrease the effectiveness of Bromocriptin.
• Methyldopa because side effects, including dizziness upon standing, may be increased by Bromocriptin
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