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Common name
Aromasin (Exemestane)
Synonyms: aromasin, exemestane
Description
Aromasin (Exemestane) is used to treat advanced breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox) for 2 to 3 years.
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Active Ingredients:
Exemestane
Therapeutic actions:
Breast cancer cell growth may be estrogen-dependent. Aromatase is the principal enzyme that converts androgens to estrogens both in pre- and post menopausal women. While the main source of estrogen (primarily estradiol) is the ovary in premenopausal women, the principal source of circulating estrogens in post menopausal women is from conversion of adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) by the aromatase enzyme in peripheral tissues.
Estrogen deprivation through aromatase inhibition is an effective and selective treatment for some post menopausal patients with hormone-dependent breast cancer.
What is it used for?:
AROMASIN is prescribed as auxiliary treatment of post menopausal women with estrogen-receptor positive early breast cancer who have received 2 to 3 years of tamoxifen and are switched to AROMASIN for completion of a total of five consecutive years of adjuvant hormonal therapy.
Contraindications and cautions:
AROMASIN Tablets should not be administered to premenopausal women.
• allergy to any ingredient in Aromasin
• not undergone menopause
• pregnancy or breast-feeding
• taking any medicines that contain estrogen
Side effects:
General: anxiety; back, joint, muscle, or limb pain; hot flashes; constipation; stomach pain; dizziness; fatigue; pain; flu-like symptoms; hair loss; swelling;headache; increased appetite; increased sweating; loss of appetite; nausea; sleeplessness; diarrhea; tiredness; coughing; unexplained weight gain; vomiting.
Serious allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); one-sided weakness; chest pain; severe stomach pain; confusion; numbness of an arm or leg; numbness or tingling in the skin, hands, or feet; depression; sudden severe dizziness, headache, vomiting, or fainting; swelling of the hands, legs, or feet; vision or speech changes.
Interactions:
These drugs, may interact with Aromasin:
• rifampin (Rifadin, Rimactane, Rifater);
• St. Johnis wort;
• a barbiturate such as phenobarbital (Luminal, Solfoton);
• seizure medication such as carbamazepine (Carbatrol, Tegretol) or phenytoin (Dilantin).
AROMASIN should not be co administered with estrogen-containing agents as these could interfere with its pharmacological action.
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