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Common name
Clomid (Clomiphene)
Description
Clomid is an ovulatory stimulant. It works by helping to produce more hormones that cause your ovaries to release 1 or more eggs.
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Active Ingredients:
Clomiphene
Therapeutic actions:
Clomiphene citrate is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix. It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracellular estrogen receptors. Clomiphene citrate initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular rupture. The first endocrine event in response to a course of clomiphene therapy is an increase in the release of pituitary gonadotropins. This initiates steroidogenesis and folliculogenesis, resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. Following ovulation, plasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle. Available data suggest that both the estrogenic and antiestrogenic properties of clomiphene may participate in the initiation of ovulation. The two clomiphene isomers have been found to have mixed estrogenic and antiestrogenic effects, which may vary from one species to another. Some data suggest that zuclomiphene has greater estrogenic activity than enclomiphene. Clomiphene citrate has no apparent progestational, androgenic, or antiandrogenic effects and does not appear to interfere with pituitary-adrenal or pituitary-thyroid function. Although there is no evidence of a &idquo;carryover effect” of CLOMID, spontaneous ovulatory menses have been noted in some patients after CLOMID therapy.
What is it used for?:
• Anovulatory infertility;
• Dysfunctional uterine bleedings;
• Amenorrhea;
• Galactorrhea;
• Polycystic ovary (Stein-Leventhal syndrome);
• Chiariis syndrome;
• Androgenous deficiency;
• Oligospermia;
• For gonadotropic hypophysisi function disorder diagnostics.
Contraindications and cautions:
• allergy to any ingredient in Clomid
• pregnancy
• abnormal vaginal bleeding
• ovarian cysts (small growths on the ovaries) or enlargement not due to polycystic ovarian syndrome
• you have or have ever had blockage of blood vessels (blood clots) in the legs, lungs, or other parts of the body
• liver problems, uncontrolled thyroid or adrenal gland problems, or a brain lesion (eg, pituitary gland tumor)
• endometriosis or endometrial carcinoma;
Side effects:
Allergic reaction may occur: difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives.
Other: ovarian enlargement presenting as abdominal or pelvic pain, tenderness, pressure, or swelling; flushing; nausea, vomiting, or diarrhea; headache; blurred vision or other visual disturbances; breast tenderness or discomfort; abnormal uterine bleeding.
Interactions:
There are no known interactions between clomiphene and other medicines
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