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Common name
Zocor (Simvastatin)
Description
Zocor is used to lower the level of cholesterol and other fats in the blood. This may help to prevent medical problems caused by cholesterol clogging the blood vessels.
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Active Ingredients:
Simvastatin
Therapeutic actions:
In the organism Simvastatin as the inactive lactone is exposed to hydrolysis with formation of the corresponding hydroxyl acid derivative. The latter represents the major metabolite rendering inhibitory action on 3-hydroxy-3-methylglutaryl-CoA - reductase, enzyme, catalyzing initial and limiting the speed of the cholesterol biosynthesis stage. As a result, as it has been shown in clinical researches, Zocor reduces the total cholesterol in blood plasma, low-density the lipoproteins (LDL) and very low-density lipoproteins (VLDL). Zocor causes lowering of the triglyceride content in plasma, and also the moderate rise of the high density lipoproteins (HDL) content and, thus, reduces correlation of LDL/VLDL and the total cholesterol/HDL.
What is it used for?:
Zocor lowers high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL, "good") cholesterol levels. It is used in certain patients to reduce the risk of heart attack, stroke, and death from the coronary heart disease. It is also used to reduce the need for medical procedures to open the blocked blood vessels. It is also used in certain patients to reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina. It may also be used for other conditions as determined by your doctor. Zocor is an HMG-CoA reductase inhibitor, also known as a "statin." It works by reducing the production of certain fatty substances in the body, including cholesterol.
Contraindications and cautions:
• allergy to any ingredient of Zocor
• liver problems or unexplained abnormal liver function tests
• pregnancy or breast-feeding
• taking a macrolide antibiotic (eg, clarithromycin, erythromycin), an HIV protease inhibitor (eg, ritonavir), itraconazole, ketoconazole, mibefradil, nefazodone, or telithromycin Some medical conditions may interact with Zocor.
Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
• if you are planning to become pregnant
• if you are taking any prescribed or unprescribed medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have low blood pressure, kidney problems, diabetes, a serious infection, or a history of seizures
• if you have metabolism, hormonal, or electrolyte problems
• if you drink alcohol or have a history of liver problems or alcohol abuse
• if you have recently had major surgery or a serious injury
Side effects:
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using simvastatin and call your doctor at once if you have any of these serious side effects:
• muscle pain, tenderness, or weakness with fever or flu symptoms and dark colored urine.
Less serious side effects may include:
• mild stomach pain, gas, bloating, stomach upset, heartburn;
• nausea;
• constipation; or
• diarrhea.
Interactions:
Some MEDICINES MAY INTERACT with Zocor .
Tell your health care provider if you are taking any other medicines, especially any of the following:
• Amiodarone, certain azole antifungals (eg, itraconazole, ketoconazole), danazol, diltiazem, fibrates (eg, gemfibrozil, clofibrate), fluconazole, HIV protease inhibitors (eg, ritonavir), imatinib, immunosuppressants (eg, cyclosporine), macrolide antibiotics (eg, clarithromycin, erythromycin), mibefradil, nefazodone, niacin, non-nucleoside reverse transcriptase inhibitors (eg, delavirdine), risperidone, streptogramins (eg, dalfopristin), telithromycin, vasopressin receptor antagonists (eg, conivaptan), verapamil, or voriconazole because they may increase the risk of muscle or kidney problems
• Bosentan, carbamazepine, rifampin, or St. John's wort because they may decrease Zocor 's effectiveness
• Anticoagulants (eg, warfarin), digoxin, macrolide immunosuppressants (eg, tacrolimus), or spironolactone because the risk of their side effects may be increased by Zocor
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Zocor brands
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Product |
Manufacturer |
Price |
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Simvagamma 10
100 tablets (10 mg/tablet)
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Worwag Pharma, Germany |
$29.00 |
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Simvagamma 10
30 tablets (10 mg/tablet)
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Worwag Pharma, Germany |
$14.00 |
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Simvagamma 20
100 tablets (20 mg/tablet)
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Worwag Pharma, Germany |
$55.00 |
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Simvagamma 20
30 tablets (20 mg/tablet)
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Worwag Pharma, Germany |
$22.00 |
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Simvagamma 40
30 tablets (40 mg/tablet)
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Worwag Pharma, Germany |
$42.00 |
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Simvagamma 40
100 tablets (40 mg/tablet)
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Worwag Pharma, Germany |
$79.00 |
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Simvalimit
30 tablets (20 mg/tablet)
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Grindex, Latvia |
$29.00 |
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Zosta
50 tablets (10 mg/tablet)
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USV Limited, India |
$21.00 |
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Zosta
50 tablets (20 mg/tablet)
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USV Limited, India |
$36.00 |
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